Boceprevir (Oral Route) Description and Brand Names - Mayo.
Boceprevir is a man-made antiviral medication that targets hepatitis C virus ().Similar drugs include simeprevir and telaprevir ().These drugs are called direct-acting antiviral agents because they act directly on hepatitis C virus. They block the replication of hepatitis C virus in human cells by binding to and inhibiting protease enzymes that HCV use for reproducing.
This compound is ak ey intermediate in the synthesis of boceprevir,adrug treatment for hepatitis C. (47) Prior to these studies the same concept was used to generate an intermediate for the.
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Boceprevir is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of chronic hepatitis C virus (HCV) genotype 1 infection. The drug is approved for use in adults whose liver is damaged but still functioning and who have not been treated yet or who did not respond to previous treatment with the medicines interferon and ribavirin.
Beta-nitroisosafrole is a less used precursor, but there is a large literature on the synthesis and reduction of nitro alkenes. This synthetic route isn't as popular due to the easier availability of precursors for MDP-2-P, and it also results in MDA which must then be further processed to give MDMA or any other N-alkyl homolog of MDA.
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An efficient multi-gram synthesis of (1R,2S,5S)-methyl 6,6-dimethyl-3-azabicyclo(3.1.0)hexane-2-carboxylate, a key chiral bicyclic proline fragment employed in the construction of the potent anti-HCV drug boceprevir, has been presented. The synthetic route commences with the readily available cis-cypermethric acid, a cheap source of the.